Short answer, No.
Long answer, it depends on your risk appetite and conviction in the trade. But there will always be certain situations (like the covid crash) which would give you a huge overnight loss if you happen to be caught on the wrong side! Such black swan events may end up eating your years' of profits or even wipe you out of the market.
Always stay hedged and know your risk!
(One exception : You can go for unhedged stock option positions if you are willing to settle the contract with cash if it expires ITM, i.e if you want to take delivery or give delivery of the underlying asset at a certain price level)